Tag Archives: IKM

Could Trophoblasts be the Immune Cells of Pregnancy?

Line TangeråsGuro StødleBlogger: Guro Stødle and Line Tangerås
PhD students, CEMIR

 

In the human body, infections (caused by bacteria or virus) and tissue injury may set off an inflammatory response, in which immune cells, blood vessels, proteins and other mediators work together to eliminate the threat and repair the damage.

Gravid magePregnancy is a delicate setting where the mother and fetus must adapt properly to each other to coexist, and an inflammatory response can disturb this delicate balance and cause complications. This is seen in preeclampsia, a potentially severe inflammatory pregnancy disorder threatening both the mother and fetus.

In preeclampsia, inflammation in the placenta contributes to poor placental development, later leading to systemic inflammation in the mother, manifesting as high blood pressure and protein in the mother’s urine.

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Filed under NTNUmedicine, Reproductive Health and Childbirth, Research

Honorary doctorate to Nobel Laureate Bruce Beutler

Professor Bruce Beutler

Professor Bruce Beutler.
Photo: Holger Motzkau / Wikimedia Commons

The Board of the Norwegian University of Science and Technology, NTNU, has decided to award Professor Bruce Beutler an honorary doctorate, the degree of doctor honoris causa. The appointment of Beutler recognizes his significant contributions to understanding how innate immune cell receptors regulate inflammatory responses.

Butler was awarded the Nobel Prize in Physiology or Medicine in 2011 for his research on innate immunity. He shared the prize with med Jules A. Hoffmann and Ralph M. Steinman.

Bruce Beutler’s groundbreaking discoveries about sensors in our innate immune system that recognize bacteria have led to an explosion of research on this theme.  Beutler’s work has greatly inspired scientists at NTNU’s Centre of Molecular Inflammation Research (CEMIR) working in the same field as him.

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Filed under Inflammatory and Immune System, NTNUmedicine, Research

The Black Death bacteria continues to kill

Egil Lien med verneutstyr

Egil Lien wearing safety gear at the lab.

It took almost six months for Egil Lien to get permission from the Federal Bureau of Investigation in the US to study the plague bacteria that, in its time, killed half of Norway’s population. Now, an antibiotic-resistant strain of the bacteria has been found.

As the bacteria responsible for killing a large part of Europe’s population during the Black Death, the plague bacteria Yersinia pestis has a long kill list on its conscience.

Read more at Gemini.no

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Filed under Inflammatory and Immune System, NTNUmedicine, Research

Early markers of a potentially dangerous type of prostate cancer

Morten Beck RyeBloggers: May-Britt Tessemansattebilde.may-britt.tessem and Morten Beck Rye

As we speak there are no accurate methods to diagnose potentially dangerous prostate cancer in an early stage of cancer.

From a pathologist’s point of view, aggressive cancers look totally similar to harmless subtypes in the beginning of development. As a consequence, the patients will be at high risk of overtreatment in the majority of cases where prostate cancer is detected. We urgently need new tools and markers to sort out the potentially dangerous types of prostate cancer from the non-dangerous in early disease. Most importantly, this will save the patients from reduced quality of life due to unnecessary surgical interventions, and also be economically beneficial for society.

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Filed under Cancer, Research

The Integrated University Hospital improves patient care

Blogger: Bjørn GustafssonBjørn_Gustafsson_blid_Foto_GeirMogen
Dean of Research, The Faculty of Medicine, NTNU

Last week one of our research groups, led by Professor Duan Chen, published a comprehensive scientific study showing promising results in treating gastric cancer, by blocking the tumor nerve supply. The article was published in the prestigious journal Science Translational Medicine.

From left: The Knowledge Center, Chun-Mei Zhao, Gøran T. Andersen (in the background), Duan Chen bottom right

From left: The Knowledge Center, Chun-Mei Zhao, Gøran T. Andersen (in the background), Duan Chen bottom right (Photo: Helsebygg/Geir Mogen)

The term “translational medicine” involves transferring new knowledge from basic research on for instance cell culture or animal models to practical use in patient care; also coined with the term “from bench-to-bedside”.

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Filed under Cancer, NTNUmedicine, Opinions, Oral and Gastrointestinal, Research

CEMIR seminar in Trondheim, September 4, 2014

The Centre of Molecular Inflammation Research, CEMIR, will hold the annual scientific seminar on inflammation research on September 4, 2014.

Speakers include the renowned professors

Cemir collage seminar

Clockwise from top left: Alan Aderem, Göran Hansson, Stefanie Vogel and Douglas Golenbock

The invited speakers will relate to the inflammation research area in different ways.

The seminar is open for all and you do not need to register in avance to participate.

CEMIR was established in 2013 as a Centre of Excellence appointed by the Research Council of Norway. The vision of CEMIR is to lay the foundation for identifying new therapeutic targets and developing new diagnostic tools for inflammatory diseases through an integrated 10-year programme of research and research training in molecular innate immune responses. CEMIR is hosted by the Faculty of Medicine at the Norwegian University of Science and Technology (NTNU).

Please find the full seminar program and see the titles of the talks here: CEMIR seminar 2014 programme (pdf)

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Filed under Inflammatory and Immune System, NTNUmedicine, Research

Treating cancer with botox

Gøran Andersen og Duan Chen.

Gøran Andersen and Duan Chen. (Foto: Geir Mogen)

In laboratory tests at The Faculty of medicine, NTNU, Botox proved highly effective at suppressing gastric cancer in mice.

The promising results have led to the launch of an early clinical trial involving human patients with stomach cancer in Norway and St. Olavs Hospital.

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Filed under Cancer, NTNUmedicine, Research

Cortisone does not relieve cancer pain

Blogger: Ørnulf PaulsenØrnulf-Paulsen-WEB

Ørnulf Paulsen is a PhD student at European Palliative Care Research Centre, NTNU, and Senior Consultant in palliative medicine at Telemark Hospital

Until now, clinicians have assumed that corticosteroids effectively relieve pain in cancer patients. A new study shows that this is not the case.

The results from our study have recently been published in the acknowledged Journal of Clinical Oncology.

Placebo shows same effect

Corticosteroids are widely used for the most advanced cancer patients, and pain treatment is one of the indications. The pain relieving effect, however, has never been documented in research results. Our study showed that the drug had no pain relieving effect for the cancer patients who participated in the study.

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Filed under Cancer, NTNUmedicine, Research

Ask a researcher: Is the 5:2 diet healthy for women?

Question

Is the 5:2 diet healthy for women?

 

Answer from Catia Martins Catia Martins. Photo: Geir Mogen

 

 

 

5:2 diet is a type of intermittent fasting, which involves a “feed day”, where food is consumed ad libitum over a 24-hours period, alternated with a “fast day” where food intake is completely or partially restricted over 24 hours. The fasting days usually vary between 2-4 days/week.

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Filed under Metabolic and Endocrine, NTNUmedicine, Spør en forsker

Taking care of knowledge

Kuiper_TrondheimAstrid Lægreid. Foto: Geir MogenBloggers: Astrid Lægreid, professor, Department of Cancer Research and Molecular Medicine and Martin Kuiper professor, Department of Biology

 

 

 

It is often overlooked that after you publish your research results you have not necessarily provided your new knowledge to your colleagues in the best possible way. Today’s biomedical science is very much dependent on the use of computers, to analyse and integrate the various types of data and facts that you and your fellow scientists have produced.  And whereas a computer can do many things, it has difficulty in understanding what is so easily understood by us when we read a scientific publication.

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Filed under NTNUmedicine, Research