Tag Archives: CEMIR

CEMIR received Young Research Talents grant (FRIPRO) from the Research Council of Norway

Two researchers at CEMIR, Atle Granlund and Richard Kandasamy have received the “Young Research Talents” – grants that is a part of the FRIPRO-funding (Norwegian link) for researchers early in their career.  FRIPRO is an open, national competitive arena that covers all fields of research. It aims to promote scientific quality at the forefront of international research, boldness in scientific thinking and innovation, careers for young research talents and mobility for researchers early in their career. FRIPRO aims to contribute to strengthen Norway’s national knowledge base by funding broad-based, independent research, that is a prerequisite for all other research and is essential for future industrial development and for policymaking. Continue reading

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Tuberculosis – a complex enigma

Blogger: Jane Atesoh Awuh, Postdoctoral Fellow, Department of Cancer Research and Molecular Medicine and Centre of Molecular Inflammation Research (SFF-CEMIR).20161125_133429 crop

Most often we become passionate and involved in issues in this life for very personal reasons. I am particularly drawn to infectious diseases because I hail from a society that is plagued by one kind of infection or the other. If you are not killed by one infectious disease you will be by the other, and if not by disease, it will be by war or hunger. I know two relatives who died of tuberculosis, one of them only a couple of months ago. Tuberculosis (TB) is still a disease of poverty although there is increasing incidence even in developed countries. HIV and TB are a dangerous liaison wherein HIV infects and destroys the very cells that should protect us from TB. These diseases are still considered shameful and surrounded by stigma. Continue reading

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Filed under Infection, Inflammatory and Immune System, NTNUmedicine, Research

Mapping the antiviral innate immune defense system

Trondheim 03.06.2016: Richard Kumaran Kandasamy, Onsager Fellow and Associate Professor, Centre of Molecular Inflammation Research (SFF-CEMIR), Norwegian University of Science and Technology. Photo: Thor Nielsen.

Blogger: Richard Kumaran Kandasamy Associate Professor and Onsager Fellow at Centre of Molecular Inflammation Research (SFF-CEMIR)

Our innate immune system is the first and most important barrier of microbial threats such as viruses and bacteria.  It will sense, and in most cases, clear out these pathogens – but not always. A new approach to studying macrophage response to viral threats have resulted in a vastly expanded knowledgebase of the dynamics of the host response to viral infection, and in turn how antiviral innate immunity works. The data is freely available at www.infectome-map.org. Continue reading

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Menno Oudhoff receives research funding from the Norwegian Cancer Society

Menno Oudhoff, researcher at CEMIR, received 6,5 million kroner from the Norwegian Cancer Society today. He was one of 34 recipients in the country, which in total received  180 million.

Anne Lise Ryel, Secretary-General in the Society, highlighted the research on big patient groups like gastrointestinal cancers. – This can really make a difference, colorectal cancer are among the cancer types that affects the most people. The chosen projects is top class, also in international standards, and they will contribute to prevention and treatment.  As a result even more people can live longer and better with cancer. Continue reading

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New insight in the development of immunity to parasitic worms

Menno-Oudhoff-Foto-Jacob-jensen-BloggBy Menno Oudhoff,
Researcher, Centre of Molecular Inflammation Reseach (CEMIR)

 

 

The gastrointestinal tract is a common site for infection by a variety of pathogens. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. For example, gut-dwelling parasitic worms currently infect over a billion people, mostly in developing nations. Deworming strategies have been shown to improve physical and intellectual development of infected children, but current therapies do not offer a sustainable solution.

Trichuris worms

Intestinal tissue infected by Trichuris worms

We still have too little insight into how these pathogens are causing disease and how immunity to them is regulated.

Group leader at Centre of Molecular Inflammation research (CEMIR) Menno Oudhoff, together with scientists in Vancouver and Melbourne, have published results from a recent study in PLOS Pathogens. Their study shows that SETD7, an enzyme that modifies the function of other proteins by methylation, plays an important role in the development of intestinal immunity to the helminth parasite Trichuris muris. Specifically, they show that SETD7 affects intestinal epithelial turnover, a key mechanism through which T. muris worms are extruded from the body.

The studies identify pathways that are important for immunity to infection, that were previously believed to be involved primarily during embryonic development.

Research article:

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection

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Filed under Infection, Inflammatory and Immune System, NTNUmedicine, Research

Successful international conference on molecular inflammation in Trondheim

May 30th – June 2nd CEMIR organized an international conference on mechanisms of molecular inflammation. The venue was Kunnskapssenteret at NTNU/ St. Olavs Hospital.

 CEMIR director Terje Espevik opened the conference


CEMIR director Terje Espevik opened the conference. Photo: Ann-Charlotte Iversen

200 delegates from 20 different countries participated and made this conference an important arena to foster further innovative research on molecular mechanisms and regulation of inflammation. The conference brought together scientists from basic and clinical research and provided significant insight into common underlying processes of inflammatory disorders that can be translated to clinical settings. Continue reading

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Richard Kandasamy receives Onsager Fellowship

RKandadsamiAssociate Professor Richard Kumaran Kandasamy at the Centre of Molecular Inflammation Research has received an Onsager Fellowship at NTNU. The Onsager Fellowship Programme is designed to recruit young, internationally recognized researchers to strengthen the university’s academic community.

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Cyclodextrin, a sugar with promising potential for treatment of atherosclerosis!

Bloggers: Siril S. Bakke and Terje Espevik, researchers at CEMIRBakke-og-Espevik

Cardiovascular disease resulting from atherosclerosis is one of the most common causes of death worldwide. Inflammation plays a crucial role in atherosclerosis and cholesterol crystals are candidate triggers early in the development of the disease. Continue reading

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Filed under Cardiovascular, NTNUmedicine, Research

CEMIR Annual Report 2015

CEMIR_AnnualReport_2015_LAST-VERSION-1CEMIR has released its 2015 Annual Report. The scientific activities at CEMIR have proceeded with very good progress. In 2015, 77 papers have been published. CEMIR researchers have published a total of 144 articles since 2013, several in high quality journals like Journal of Immunology, Nature, Nature Immunology, Autophagy and PNAS. Eight PhD Candidates completed their theses at the centre in 2015.

Read more about these results and more scientific highlights in the annual report:
CEMIR Annual Report 2015 (pdf)

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Unveiling connections between preeclampsia and cardiovascular disease

Women with preeclampsia have up to eight times higher risk of later developing cardiovascular disease. CEMIR’s research group on Inflammation and Genetics in Pregnancy studies how the development of preeclampsia and cardiovascular disease are connected.

ISSHP

Liv Cecilie Vestrheim Thomsen (left) and Lobke Gierman.

The group has recently unveiled inflammatory mechanisms in the placenta and identified an important role for fetal trophoblasts. They have also identified a gene variant that is protective for both preeclampsia and cardiovascular disease.

This research was recently presented at the International Society for the Study of Hypertension in Pregnancy (ISSHP), a conference about research and treatment of hypersensitive diseases during pregnancy, primarily preeclampsia and gestational hypertension.

Researcher Liv Cecilie Vestrheim Thomsen received the prize for best poster and Post.doc. Lobke Gierman received third place in the category best oral presentation.

Article in Placenta:   Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

 

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Filed under Cardiovascular, Inflammatory and Immune System, NTNUmedicine, Reproductive Health and Childbirth, Research